The Prevalence of Non-alcoholic Fatty Liver Disease and Diabetes Mellitus in an Iranian Population

Behnam Rabiee, Farzin Roozafzai, Gholam Reza Hemasi, Hossein Poustchi, Hossein Keyvani, Mahmood Reza Khonsari, Hossein Ajdarkosh, Mansooreh Maadi, Fatemeh Sima Saeedian, Farhad Zamani



Type II diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are important
causes of morbidity and mortality worldwide. We aimed to estimate the prevalence of DM in the context of NAFLD.


In this cross-sectional study, we studied 5052 participants, aged 18 years and older, of a baseline population-based cohort in northern Iran (N=6143). The prevalence of DM was estimated in individuals with and without NAFLD. The association between NAFLD and T2DM was evaluated using logistic regression with the adjustment of confounding effects of age, sex, body mass index, lipid profiles, and fasting insulin.


In men, the prevalence (95% confidence interval) of T2DM was 5.34% (4.35%-6.34%) and
15.06% (13.12%-17.00%) in individuals without and with NAFLD, respectively (p <0.001). In women without NAFLD, the prevalence was 8.27% (6.83%-9.71%) while in the presence of NAFLD, the prevalence was 27.21% (24.59%-29.83%), (p <0.001). In univariate analysis, the chance of having T2DM was 3.700 (3.130-4.380) times more in patients with NAFLD compared with subjects without NAFLD (p<0.001). This chance was reduced (Odds Ratio=1.976, 95% CI: 1.593-2.451, p <0.001) after removing the effects of other variables.


The prevalence of T2DM is increased in the context of NAFLD. This condition may be considered as an independent predictor of T2DM.


Non-alcoholic fatty liver disease, Diabetes mellitus, Non-communicable disease, Prevalence, Iran

Full Text:


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.