Rome IV Diagnostic Criteria for Functional Gastrointestinal Disorders in Patients with Chronic Hepatitis C Virus

Alshymaa Hassnine, Zeinab Saad



Patients with chronic hepatitis C virus (HCV) usually have different abdominal complaints without any organic lesions. The functional cause of these complaints is claimed in most patients. Aim: To evaluate functional gastrointestinal disorders (FGID) in patients with chronic hepatitis C using Rome IV diagnostic criteria.


 This study included 1506 participants (1006 patients with chronic HCV, and 500 controls). All individuals were subjected to taking thorough medical history, basic investigations (complete blood counts, liver and renal functions tests, INR (international normalized ratio), alpha- fetoprotein, HCV RNA PCR (polymerase chain reaction0, abdominal ultrasonography, and upper gastrointestinal tract (GIT) endoscopy for patients only), and Rome IV diagnostic questionnaire.


Patients with HCV had symptoms of functional gastrointestinal disorders including functional dyspepsia (FD) (p = 0.009), early satiety (p = 0.002), postprandial distress (p = 0.02), epigastric pain (p = 0.03), irritable bowel syndrome (IBS) (p < 0.001), IBS predominant constipation (p < 0.001), IBS predominant diarrhea (p < 0.001), and IBS mixed (p < 0.001). There were multiple factors for the prediction of FD in patients with HCV, including high body mass index (BMI), education level, positive PCR, and fibrosis stage. Also, there were multiple factors for the prediction of IBS in patients with HCV, including male sex, high BMI, urban residence, education level, positive PCR, and fibrosis stage.


FD is a prevalent finding in obese patients with HCV and with higher fibrosis scores. IBS is also prevalent in male patients with HCV.


Rome IV diagnostic criteria; Hepatitis C virus; Functional gastrointestinal disorders; Functional dyspepsia; Irritable bowel syndromes

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