Gut Microbiota Modification via Glucagon-like Peptide-1 with Beneficial Neuroprotective Effects

Fatemeh Sayehmiri, Mohammad Samadian, Ashraf Mohamadkhani, Abbas Tafakhori, Somayeh Haghighat, Aryoobarzan Rahmatian, Mohammad Ali Mohammadkhani, Hamid Reza Fazli, Mostafa Tavirani Rezaei



 In recent decades, it has been shown that the association between intestinal bacterial imbalance (dysbiosis) and various diseases such as type 2 diabetes can play a role in the development of Alzheimer's and Parkinson's diseases.  In this study, the beneficial effects of intestinal microbiota glucagon-like peptide 1 in cognitive disorders were investigated.


 PubMed-Medline, Web of Science, and Scopus were searched to identify experimental studies based on the bacterial strains along with glucagon-like peptide 1 expression in preventing or reducing cognitive impairment. Of the 233 studies, six were eligible for inclusion, and the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool was used to evaluate the risk of bias in individual studies.


 The results showed that intestinal expression of glucagon-like peptide 1 could reduce the intestinal pathogenic genus such as Enterobacteriaceae and was obviously associated with a greater number of beneficial genera such as Lactobacillus and Akkermansia. Also, the neuroprotective effects of Clostridium butyricum with glucagon-like peptide 1 in a mice were approved. Therefore, the modulation of the intestinal microbiota, mediated by an increase in the intestinal glucagon-like peptide 1 level, consequently improved cognitive function.


In this review, we have indicated that the gut microbiota, by stimulating the expression of the intestinal hormones like glucagon-like peptide 1, and also with a beneficial effect in inhibiting some involved genes in inflammation, can declined the development of cognitive disorders.


Gastrointestinal microbiome; Glucagon-like peptide 1; Alzheimer disease; Parkinson disease; Neurodegenerative diseases

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